Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Submit Manuscript | http://medcraveonline.com Abbreviations: HPMC: Hydroxypropyl Methylcellulose; MC: Methylcellulose; PLGA: Poly (Lactide-co-Glycolide); CAP: Cellulose Acetate Phthalate; LCST: Low Critical Solution Temperature; UCST: Upper Critical Solution Temperature; PPO: Polypropylene Oxide; PEO: Polyethylene Oxide; MTA: Methozolamide; PNIPAAm: Poly (N-Isopropylacrylamide); GC: Guluronic A...

in situ gelling systems for drug delivery

In Situ Gelling Systems for Drug Delivery

Implication for health policy/practice/research/medical education: Development of polymeric in situ gels for controlled release of various drugs provides a number of advantages over conventional dosage forms. Some important advantages of these smart systems are ease of application and reduced frequency of administration, as well as protection of the drug from environmental conditions. Published...

A Study on Stability and in Vivo Drug Release of Naphazoline and Antazoline in Situ Gelling Systems for Ocular Delivery

This work describes the stability of the selected in situ solutions for ophthalmic delivery of naphazoline hydrochloride ( FF17, FF18) and antazoline phosphate ( GG17 and GG18) based on the pH triggered concept using Carbopol 940 and HPMC K4M. The formulations were evaluated for their pH, isotonicity, gelling capacity, rheological characteristics, in vitro drug release , sterility and in vivo s...

Newer drug delivery systems in anesthesia

A paradigm shift in drug delivery systems have been noted recently. The focus nowadays is to obtain maximum benefit with lower side effects. It is a monetary burden to launch newer molecules hence the industry is concentrating on improving the efficacy of existing molecules. Thus controlled release, target controlled infusion and closed loop infusion have entered the scene. Applying pharmacokin...